Vaccine-derived poliovirus from long term excretors and the end game of polio eradication

被引:41
|
作者
Martín, J [1 ]
机构
[1] Natl Inst Biol Stand & Controls, Div Virol, Potters Bar EN6 3QG, Herts, England
关键词
vaccine derived polioviruses; excretion; immunodeficiency; adaptive changes; molecular evolution; virus shedding;
D O I
10.1016/j.biologicals.2006.02.005
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Seven cases of long-term poliovirus excretion in the UK and Ireland are reviewed in this paper. They include a rare case of long-term virus excretion by a healthy child recently found in Ireland and the case with the longest period of vaccine-derived poliovirus excretion by an immuno-deficient individual ever known, 18 years. The evolution of viral properties such as antigenic structure, neurovirulence, sensitivity for growth at high temperatures, and differences in nucleotide sequence from the Sabin vaccine strains were studied in detail. The relevance of these cases in the context of the global polio eradication initiative and the design of vaccination strategies for the last stages of eradication and the post-eradication era are discussed. (c) 2006 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:117 / 122
页数:6
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