Air pollution causes poor air quality and visibility reduction, which will affect traffic safety and life quality. Progressive technologies provide people a comfortable life, but also bring some kind of pollution, and endanger human health. The low air quality caused by air pollution and related diseases caused by ultraviolet light are all major factors related to the environment and have an impact on long-term health. In particular, they impact persons in hospitals, schools, factories, and other living spaces. The related applications of portable devices are no longer confined to Internet of Things (IoT) services. Many providers are committed to provide various applications and bring more commercial possibilities with portable devices. With new kinds of products, more emphasis has been placed on consumer experience and human-related applications. This research is focused on developing a portable wireless environmental and medical assistance sensing system. It is a sensing system that combines airborne particle, temperature, humidity, and UV measurements, and wireless function. It can be placed in any workplace or home environment for real-time measurement and used with IoT. It can upload data to remote servers, and one can check them using laptops, computers, and smart phones, with the environmental warning light indicator being active to protect oneself.