RNA polymerase beta' subunit: A target of DNA binding-independent activation

被引：58
|
作者：
Miller, A
Wood, D
Ebright, RH
RothmanDenes, OB
机构：
[1] UNIV CHICAGO,DEPT MOL GENET & CELL BIOL,CHICAGO,IL 60637
[2] UNIV CHICAGO,DEPT BIOCHEM & MOL BIOL,CHICAGO,IL 60637
[3] RUTGERS STATE UNIV,DEPT CHEM,NEW BRUNSWICK,NJ 08855
[4] RUTGERS STATE UNIV,WAKSMAN INST,NEW BRUNSWICK,NJ 08855
来源：
SCIENCE | 1997年 / 275卷 / 5306期
关键词：
D O I：
10.1126/science.275.5306.1655
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The bacteriophage N4 single-stranded DNA binding protein (N4SSB) activates transcription by the Escherichia coli sigma 70-RNA polymerase at N4 late promoters. Here it is shown that the single-stranded DNA binding activity of N4SSB is not required for transcriptional activation. N4SSB interacts with the carboxyl terminus of the RNA polymerase beta' subunit in a region that is highly conserved in the largest subunits of prokaryotic and eukaryotic RNA polymerases.
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页码：1655 / 1657
页数：3
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