Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy

被引:31
|
作者
Gehl, Julie [1 ]
Geertsen, Poul F. [1 ]
机构
[1] Univ Copenhagen, Herlev Hosp, Dept Oncol 54B1, DK-2730 Herlev, Denmark
来源
EJC SUPPLEMENTS | 2006年 / 4卷 / 11期
关键词
bleeding lesions; melanoma; cutaneous metastases; haemorrhaging skin lesions; electrochemotherapy;
D O I
10.1016/j.ejcsup.2006.07.007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
By short, intense electric pulses it is possible to cause cell permeabilisation (electroporation) and this can be used to deliver chemotherapy to tumours (electrochemotherapy). Preclinical studies have shown effects on vasculature of electroporation. and electrochemotherapy, in particular in tumours. The effect on normal vasculature is a brief reflexory constriction; however in the fragile and abundant vasculature of tumours, a direct anti-vascular effect has been shown. This finding is mirrored in the clinical observation that bleeding, ulcerated lesions cease to bleed after application of electric pulses, and stay dry while the involution of tumours due to uptake of the cytotoxic agent takes place. Ulcerated, bleeding lesions are not uncommon in cancer patients, and cause discomfort due to bleeding and also stigmatisation when lesions are in visible areas. This report describes a case with ulcerated, bleeding lesions where the use of electrochemotherapy has led to efficient and immediate relief of symptoms. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:35 / 37
页数:3
相关论文
共 50 条
  • [31] Electrochemotherapy as Treatment of Cutaneous and Subcutaneous Melanoma Metastases
    Ruggeri, R.
    Patuzzo, R.
    Gallino, G.
    Maurichi, A.
    Camerini, T.
    Mattavelli, I
    Crippa, F.
    Moglia, D.
    Tolomio, E.
    Santinami, M.
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2013, 11 : 53 - 53
  • [32] An ulcerated umbilical nodule -: Primary cutaneous endometriosis
    Muñoz, H
    Waxtein, L
    Vega, ME
    Cortes, R
    Hojyo, MT
    Dominguez-Soto, L
    ARCHIVES OF FAMILY MEDICINE, 2000, 9 (06) : 501 - 502
  • [33] A challenging case of severe ulcerated cutaneous lesion
    Elisa Costantini
    Massimiliano Carlin
    Massimo Porta
    Maria Felice Brizzi
    Internal and Emergency Medicine, 2022, 17 : 269 - 271
  • [34] Vascularization of the tumours affects the pharmacokinetics of bleomycin and the effectiveness of electrochemotherapy
    Groselj, Ales
    Kranjc, Simona
    Bosnjak, Masa
    Krzan, Mojca
    Kosjek, Tina
    Prevc, Ajda
    Cemazar, Maja
    Sersa, Gregor
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 123 (03) : 247 - 256
  • [35] AN ULCERATED PLAQUE IN A GAY MAN - CUTANEOUS CRYPTOCOCCOSIS
    LUI, H
    MCLEOD, WA
    WOOD, WS
    ARCHIVES OF DERMATOLOGY, 1993, 129 (04) : 497 - +
  • [36] Calculation of the electrical parameters in electrochemotherapy of solid tumours in mice
    Semrov, D
    Miklavcic, D
    COMPUTERS IN BIOLOGY AND MEDICINE, 1998, 28 (04) : 439 - 448
  • [37] Electrochemotherapy for multiple cutaneous tumors in immunosuppressed patients
    Rozsa Petra
    Agoston Dora
    Szederkenyi Edit
    Ocsai Henriette
    Baltas Eszter
    Vass Gabor
    Kemeny Lajos
    Olah Judit
    Kis Erika
    ORVOSI HETILAP, 2023, 164 (37) : 1462 - 1468
  • [38] A challenging case of severe ulcerated cutaneous lesion
    Costantini, Elisa
    Carlin, Massimiliano
    Porta, Massimo
    Brizzi, Maria Felice
    INTERNAL AND EMERGENCY MEDICINE, 2022, 17 (01) : 269 - 271
  • [39] Electrochemotherapy palliation of an oral squamous cell carcinoma in an African hedgehog (Atelerix albiventris)
    Spugnini, Enrico Pierluigi
    Lanza, Andrea
    Sebasti, Silvia
    Baldi, Alfonso
    VETERINARY RESEARCH FORUM, 2018, 9 (04) : 379 - 381
  • [40] Aggressive surgical palliation for advanced girdle tumours
    Burd, Andrew
    Wong, K. C.
    Kumta, Shekhar M.
    INDIAN JOURNAL OF PLASTIC SURGERY, 2012, 45 (01) : 16 - 21