6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development

被引：15
|
作者：
Goren, N
Manzano, A
Riera, L
Ambrosio, S
Ventura, F
Bartrons, R
机构：
[1] Univ Barcelona, Dept Ciencies Fisiol 2, Unitat Bioquim, E-08907 Hospitalet, Spain
[2] Univ Buenos Aires, CONICET, CEFYBO, Fac Odontol,Catedra Farmacol, Buenos Aires, DF, Argentina
来源：
MOLECULAR BRAIN RESEARCH | 2000年 / 75卷 / 01期
关键词：
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase; brain glycolysis; gene expression;
D O I：
10.1016/S0169-328X(99)00319-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study reports the expression of the ubiquitous 6-phosphofructo-2-kinase/ftuctose-2,6-bisphosphatase gene (PFKFB3) (PFK-2/FBPase-2) indifferent stages of rat brain development. Northern blot and RT-PCR analysis demonstrated that ubiquitous PFK-2/FBPase-2 is expressed in rat brain from embryonic to adult life and shows a transient increase 1 day before birth, coincident with the maximum concentration of Fru-2,6-P-2 and PFK-2 activity. The levels of brain PFK-2/FBPase-2 gene expression as well as the enzymatic activity and the concentration of Fru-2,6-P-2 appear to be remarkably constant during adult life, without significant differences in the brain hippocampus, cortex, cerebellum or striatum areas. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码：138 / 142
页数：5
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