Activation-free one-pot alkynylation-cyclization synthesis of 2-substituted 4-azaindoles and indoles

被引：5

作者：

Lessing, Timo ^{[1
]}

Mueller, Thomas J. J. ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Lehrstuhl Organ Chem, Inst Organ Chem & Makromol Chem, 1 Univ Str, D-40225 Dusseldorf, Germany

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 03期

关键词：

4-azaindoles; heterocycles; indoles; alkynylation; cyclization; one-pot reaction; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; INHIBITORS; FUNCTIONALIZATION; DERIVATIVES; DISCOVERY; DESIGN; OPTIMIZATION; HETEROCYCLES; KINASES;

D O I：

10.1007/s10593-018-2269-z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Substituted 4-azaindoles and indoles are rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation-cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.

引用

页码：334 / 338

页数：5

共 50 条

[41] Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles from -Diaminoarene and Aryl Aldehydes
Alapati, Mohan Lakshmi Punna Rao
Abburi, Sridhar Rao
Mukkamala, Saratchandra Babu
Rao, M. Krishnaji
SYNTHETIC COMMUNICATIONS, 2015, 45 (21) : 2436 - 2443
[42] One-pot synthesis of carbazoles from indoles via a metal free benzannulation
Kotha, Sambasivarao
Aswar, Vikas R.
Chinnam, Ajay Kumar
TETRAHEDRON LETTERS, 2017, 58 (46) : 4360 - 4362
[43] Highly Efficient, Environment-Friendly, One-Pot Synthesis of 2-Substituted 4-Formylimidazoles from 4-Acylaminoisoxazoles
Gao, Feng
Tian, Xin-Chuan
Qu, Xiao-Xia
Wang, Dan
Pu, Dong
SYNTHESIS-STUTTGART, 2015, 47 (01): : 65 - 70
[44] One-Pot Synthesis of 3-(2-Fluoroalkenyl)indoles
Aldoshin, Alexander S.
Tabolin, Andrey A.
Ioffe, Sema L.
Nenajdenko, Valentine G.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 2019 (27) : 4384 - 4396
[45] A CONVENIENT ONE-POT SYNTHESIS OF 2,3-DISUBSTITUTED INDOLES
SUZUKI, H
THIRUVIKRAMAN, SV
OSUKA, A
SYNTHESIS-STUTTGART, 1984, (07): : 616 - 617
[46] Facile one-pot synthesis of 4-substituted semicarbazides
Bogolubsky, Andrey V.
Moroz, Yurii S.
Mykhailiuk, Pavel K.
Dmytriv, Yurii V.
Pipko, Sergey E.
Babichenko, Liudmyla N.
Konovets, Anzhelika I.
Tolmachev, Andrey
RSC ADVANCES, 2015, 5 (02): : 1063 - 1069
[47] Ultrasound Assisted Synthesis of 2-Substituted Benzofurans via One-Pot and Sequential Method: Their In Vitro Evaluation
Rao, Bodapati V. D.
Vardhini, Suryadevara V.
Kolli, Deepti
Rao, Mandava V. B.
Pal, Manojit
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (05) : 580 - 588
[48] A simple, rapid and efficient one-pot protocol for the synthesis of 2-substituted benzothiazole derivatives and their antimicrobial screening
Rauf, Abdul
Gangal, Saloni
Sharma, Shweta
Zahin, Maryam
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE, 2008, 61 : 63 - 67
[49] New synthesis of 2-substituted azoles via a three-component one-pot reaction.
Deng, YJ
Hlasta, DJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U47 - U47
[50] One-Pot Synthesis of Some Dynamic 2-Substituted Benzoxazinones and Their Corresponding Qinazolinones of Anticipated Biological Activity
El-Hashash, Maher A.
Azab, Mohamed E.
Morsy, Jehan M.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (01) : 95 - 101

← 1 2 3 4 5 →