Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies

被引：29
|
作者：
Sorrentino, Claudia [1 ]
Cuneo, Antonio [1 ,2 ]
Roti, Giovanni [1 ]
机构：
[1] Univ Parma, Dept Med & Surg, I-43126 Parma, Italy
[2] Univ Ferrara, Dept Med Sci, I-44121 Ferrara, Italy
来源：
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2019年 / 11卷
关键词：
NOTCH1; Targeted therapy; T-cell acute lymphoblastic leukemia; Chronic lymphocytic leukemia; Mantle cell lymphoma; PROTEASOME INHIBITOR BORTEZOMIB; GAMMA-SECRETASE INHIBITORS; MANTLE-CELL LYMPHOMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; T-CELL; B-CLL; ACTIVATING MUTATIONS; MONOCLONAL-ANTIBODY; TUMOR-GROWTH; APOPTOSIS;
D O I：
10.4084/MJHID.2019.037
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The Notch pathway plays a key role in several processes, including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable targets in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients' outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and mantle cell lymphoma.
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页数：13
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