Association between manganese superoxide dismutase (MnSOD) gene polymorphism and elderly obesity

被引:42
|
作者
Echart Montano, Marco Aurelio [2 ]
Barrio Lera, Juan Pablo [2 ]
Valle Gottlieb, Maria Gabriela [3 ]
Augustin Schwanke, Carla Helena [3 ,4 ]
Ugalde Marques da Rocha, Maria Izabel [5 ]
Manica-Cattani, Maria Fernanda [5 ]
dos Santos, Greice Feyl [1 ]
Manica da Cruz, Ivana Beatrice [1 ,5 ]
机构
[1] Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Ctr Ciencias Naturais & Exatas, BR-97119900 Santa Maria, RS, Brazil
[2] Univ Leon, Dept Ciencias Biomed, Programa Doctorado Biomed, E-24071 Leon, Spain
[3] Pontificia Univ Catolica Rio Grande do Sul, Programa Posgrad Med & Ciencias Saude, Porto Alegre, RS, Brazil
[4] Pontificia Univ Catolica Rio Grande do Sul, Inst Gerontol & Geriatr, Porto Alegre, RS, Brazil
[5] Univ Fed Santa Maria, Dept Morfol, Lab Biogenom Desenvolvimento, Ctr Ciencias Saude, BR-97900105 Santa Maria, RS, Brazil
关键词
Obesity; Ala16val MnSOD polymorphism; Superoxide; Elderly; Nutrigenetics; Dietary pattern; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; BREAST-CANCER; ALA-9VAL POLYMORPHISM; PROSTATE-CANCER; AGING PROCESS; RISK; ATHEROSCLEROSIS; SOD2; ANTIOXIDANTS;
D O I
10.1007/s11010-009-0071-z
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Evidence suggests an association between obesity and oxidative stress caused by superoxide production. Since the dismutation of superoxide is catalyzed by superoxide dismutase enzymes, we tested the association between obesity and Ala16Val manganese-dependent superoxide dismutase gene (MnSOD) polymorphism. We analyzed 815 free-living community subjects (a parts per thousand yen60 years old) grouped into subjects who were either obese (BMI a parts per thousand yen 30 kg/m(2)) or non-obese (BMI < 25 kg/m(2)). Additionally, we investigated the possible interaction between the Ala16Val MnSOD gene polymorphism and obesity in the modulation of biochemical and nutritional variables. We found a positive association between MnSOD polymorphism and obesity, since higher VV frequency (28.2%) was observed in the obese group (P = 0.002, odds ratio 1.949, 95% CI: 1.223-3.008). This result was independent of sex, age, diabetes, dyslipidemia, hypertension, and metabolic syndrome. A possible biological explanation of the association described here could be a chronic state of superoxide enzyme imbalance present in VV carriers, which could affect differential metabolic pathways contributing to the obese state.
引用
收藏
页码:33 / 40
页数:8
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