An Efficient Four-Component Approach for the Synthesis of Novel 5-Methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)-1-arylethyl)-1H-pyrazol-3-ol Derivatives and their Antibacterial Study

被引：15

作者：

Muthineni, Narmada ^{[1
]}

Kumar, Nandigama Satish ^{[1
]}

Rao, L. Chandrasekhara ^{[1
]}

Kumar, V. Dileep ^{[2
]}

Misra, Sunil ^{[2
]}

Chowhan, L. Raju ^{[3
]}

Meshram, H. M. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol Div, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Div Biol, Hyderabad 500007, Andhra Pradesh, India

[3] Cent Univ Gujarat, Sch Chem Sci, Gandhinagar 38203, India

来源：

CHEMISTRYSELECT | 2016年 / 1卷 / 14期

关键词：

Anti-bacterial; 3; 5-dimethyl-4-nitroisoxazole; Efficient; Multi-component reactions (MCRs); Pyrazolone; MULTICOMPONENT SYNTHESIS; AQUEOUS-MEDIA; CATALYST-FREE; ONE-POT; INHIBITORS; WATER; 2H-CHROMENES; CHEMISTRY; DESIGN;

D O I：

10.1002/slct.201600915

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A One pot four-component domino reactions were developed for the synthesis of 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)- 1-arylethyl)-1H-pyrazol-3-ols derivatives in excellent yield from hydrazine hydrate (1), ethyl acetoacetate (2), aldehyde (3) and 3,5-dimethyl-4-nitro-isoxazole (4) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C = C, one C = N, one O = H and one C = N) in a single step. These novel 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)- 1-arylethyl)-1H-pyrazol-3-ol derivatives are evaluated as antibacterial agents.

引用

页码：4197 / 4202

页数：6

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