Harnessing G-tetrad scaffolds within G-quadruplex forming aptamers for fluorescence detection strategies

被引：20

作者：

Sproviero, Michael ^{[1
]}

Manderville, Richard A. ^{[1
]}

机构：

[1] Univ Guelph, Dept Chem & Toxicol, Guelph, ON N1G 2W1, Canada

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 23期

关键词：

THROMBIN-BINDING APTAMER; DNA; OLIGONUCLEOTIDE; STABILITY; PROBES;

D O I：

10.1039/c3cc49560d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

G-tetrads are essential structural components required for the formation of G-quadruplexes. Replacement of G nucleobases within G-tetrads with fluorescent 8-aryl-dG residues provides diagnostic handles that are universally applicable to antiparallel G-quadruplex aptamers, as they can stabilize quadruplex folding and maintain aptamer function.

引用

页码：3097 / 3099

页数：3

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