[1] Ehime Univ, Coll Agr, Matsuyama, Ehime 7908566, Japan
来源:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
|
2002年
/
19期
关键词:
D O I:
10.1039/b206843p
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Novel yeast reduction which gave (1R, 2S)-hydroxy ester 10 and (1S, 5S)-lactone 11 from racemic ketoester 12 was discovered. After 10 and 11 were converted to lactone 15 and 17, enantiomeric excesses were determined as 99% and 95%, respectively. This novel yeast reduction was applied to synthetic study of metabolites of 5-oxo-ETE 1. (R)-6,7-Dihydro- 5-HETE lactone 5 and (S)-6,7-dihydro-5-HETE lactone 6 were synthesized from 15 and 17, respectively.
机构:
Sci & Prod Co CHEM Ltd, Ul Zavodskaya 3,Bldg 142, Kuzmolovskii 188663, Leningrad Oblas, Russia
St Petersburg State Chem Pharmaceut Acad, Ul Prof Popova 14, St Petersburg 197376, RussiaSci & Prod Co CHEM Ltd, Ul Zavodskaya 3,Bldg 142, Kuzmolovskii 188663, Leningrad Oblas, Russia
Kavina, M. A.
Sizov, V. V.
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机构:
Sci & Prod Co CHEM Ltd, Ul Zavodskaya 3,Bldg 142, Kuzmolovskii 188663, Leningrad Oblas, RussiaSci & Prod Co CHEM Ltd, Ul Zavodskaya 3,Bldg 142, Kuzmolovskii 188663, Leningrad Oblas, Russia
Sizov, V. V.
Yakovlev, I. P.
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h-index: 0
机构:
St Petersburg State Chem Pharmaceut Acad, Ul Prof Popova 14, St Petersburg 197376, RussiaSci & Prod Co CHEM Ltd, Ul Zavodskaya 3,Bldg 142, Kuzmolovskii 188663, Leningrad Oblas, Russia