The variation of water resource directly restricts developing process and tendency in inland river basin. Based on hydrological process in Tarim River Basin in the western China, to approach feature and pattern of water-salt temporal and spatial changes, the coupling relation between water and salt are revealed. Salinity variation of surface runoff has close coupling relation with mineralization degree and hydrological chemical features. Before 1950s, the mineralization degree is less than 1.0g/L in the main stream of the Tarim River and water quality is not polluted. At present, the monitoring result shows that water quality in Ajar and Yingbazha is the fifth degree severely polluted water. That of in Qiala is the fourth degree polluted water in a whole year. Among them, some indicators including chloride, sulfate, mineralization degree, total hardness and fluoride severely exceed normal values. The condition objectively reflects some influence on water-salt coupling relations,and dissipation mechanism. Meanwhile, in order to keep within limits of salinity accumulation and contaminant expansion, the behavior of human beings has to be confined. Based on hydrogeochemical characteristics, there are intricate coupling relations and dissipation mechanism among surface water and soil moisture and groundwater. High F- content is an obvious characteristic in Tarim River. In addition, water quality condition decides coupling types. Agricultural drainage affects conditions of water quality. Disarrangement of water-salt relation centered by water resource and maladjustment of water-heat and water-sand and water-land balance is confined. In order to improve water quality, some reasonable measurements should be taken.