Non-coding RNAs in ossification of spinal ligament

被引：8
|
作者：
Yuan, Xiaoqiu [1 ]
Shi, Lei [1 ]
Chen, Yu [1 ]
机构：
[1] Second Mil Med Univ, Spine Ctr, Dept Orthopaed, Changzheng Hosp, 415 Fengyang Rd, Shanghai 20003, Peoples R China
来源：
EUROPEAN SPINE JOURNAL | 2021年 / 30卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Non-coding RNA; microRNA; Long non-coding RNA; Circular RNA; Osteogenesis; Ossification of spinal ligament; POSTERIOR LONGITUDINAL LIGAMENT; OSTEOGENIC DIFFERENTIATION; SIGNALING PATHWAY; GENE; POLYMORPHISM; ASSOCIATION; WNT; PROGRESSION; FLAVUM; COL6A1;
D O I：
10.1007/s00586-020-06687-y
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose Ossification of the spinal ligament (OSL) is a disease characterized by progressive ectopic ossification or calcification in the tissues of spinal ligament. The molecular pathogenesis of OSL has not been clearly elucidated. Recently, ncRNAs was found to functionally participate in OSL development. This review summarized current knowledge regarding the deregulation and function of ncRNAs in OSL Methods Relevant studies on deregulation and function of ncRNAs in OSL were retrieved from the PubMed databases. Then, studies were manually selected for inclusion based on predefined criteria. Result 14 studies were reviewed, with 4 studies about high throughput sequencing and microarray of ncRNAs, 8 studies relevant to the function of ncRNAs and 2 studies regarding the ncRNAs as the biomarker of OSL. Conclusion ncRNA play a vital role in the ossification of spinal ligament fibrocyte, including cell osteogenesis and inflammation. ncRNAs also have potential clinical utilities as therapeutic targets, risk predication and early detection in the management of OSL.
引用
收藏
页码：801 / 808
页数：8
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