2-[6,8-Dibromo-3-(4-hydroxycyclohexyl)-1,2,3,4-tetrahydroquinazolin-2-yl]-6-methoxyphenol

被引：7
|
作者：
Wang, Zhi-Gang [2 ]
Wang, Rong [1 ]
Zhang, Yi [3 ]
Zhi, Feng [1 ]
Yang, Yi-Lin [3 ]
机构：
[1] Soochow Univ, Affiliated Hosp 3, Modern Med Res Ctr, Changzhou 213003, Peoples R China
[2] Soochow Univ, Affiliated Hosp 3, Resp Dept, Changzhou 213003, Peoples R China
[3] Soochow Univ, Affiliated Hosp 3, Dept Neurosurg, Changzhou 213003, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷
关键词：
AMBROXOL;
D O I：
10.1107/S1600536809005182
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound, C21H24Br2N2O3, was synthesized by the condensation reaction of 3-methoxysalicylaldehyde with 4-(2-amino-3,5-dibromobenzylamino) cyclohexanol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3)degrees. The cyclohexyl ring adopts a chair configuration. There is an intramolecular O-H center dot center dot center dot N hydrogen bond which affects the solid state conformation of the molecule. The crystal structure is stabilized by intermolecular O-H center dot center dot center dot O hydrogen bonds, forming chains running along the b axis.
引用
收藏
页码：O550 / U2069
页数：10
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