TGF-β signaling pathway as a pharmacological target in liver diseases

被引：33
|
作者：
Zhang, Sen [1 ]
Sun, Wu-Yi [1 ]
Wu, Jing-Jing [1 ]
Wei, Wei [1 ]
机构：
[1] Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immune Med, Minist Educ, Hefei 230032, Anhui, Peoples R China
来源：
PHARMACOLOGICAL RESEARCH | 2014年 / 85卷
基金：
高等学校博士学科点专项科研基金;
关键词：
Transforming growth factor beta; Signaling pathway; Liver diseases; Pharmacological target; Targeted drugs; GROWTH-FACTOR-BETA; RECEPTOR KINASE DOMAIN; HEPATOCELLULAR-CARCINOMA; MESENCHYMAL TRANSITION; CROSS-TALK; ACTIVIN-A; INHIBITOR; CANCER; FIBROGENESIS; PROGRESSION;
D O I：
10.1016/j.phrs.2014.05.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transforming growth factor beta (TGF-beta) belongs to a class of pleiotropic cytokines that are involved in the processes of embryonic development, wound healing, cell proliferation, and differentiation. Moreover, TGF-beta is also regarded as a central regulator in the pathogenesis and development of various liver diseases because it contributes to almost all of the stages of disease progression. A range of liver cells are considered to secrete TGF-beta ligands and express related receptors and, consequently, play a crucial role in the progression of liver disease via different signal pathways. In this manuscript, we review the role of the TGF-beta signaling pathway in liver disease and the potential of targeting the TGF-beta signaling in the pharmacological treatment of liver diseases. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：15 / 22
页数：8
相关论文
共 50 条
  • [21] Sulfatase-2 Regulates Liver Fibrosis through the TGF-β Signaling Pathway
    Nakamura, Ikuo
    Asumda, Faizal Z.
    Moser, Catherine D.
    Kang, Yoo Na N.
    Lai, Jin-Ping
    Roberts, Lewis R.
    CANCERS, 2021, 13 (21)
  • [22] Mitigation of TGF-β/Smad signaling pathway-associated liver fibrosis by paeoniflorin
    Li, Wen-Zhong
    Wei, Zi-Bai
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (09) : 2107 - 2112
  • [23] Vitamin D for prevention of liver cancer in the setting of disrupted TGF-β signaling pathway
    Katz, Lior H.
    Cortes, Andrea
    Shukla, Vivek
    Machida, Keigo
    Tsukamoto, Hidekazu
    Shetty, Kirty
    He, Aiwu R.
    Johnson, Lynt B.
    Chen, Jian
    El-Zein, Randa
    Lee, Ju-Seog
    Mshra, Lopa
    CANCER RESEARCH, 2014, 74 (19)
  • [24] Ahnak depletion accelerates liver regeneration by modulating the TGF-?/Smad signaling pathway
    Yang, Insook
    Son, Yeri
    Shin, Jae Hoon
    Kim, Il Yong
    Seong, Je Kyung
    BMB REPORTS, 2022, 55 (08) : 401 - 406
  • [25] Vitamin D for prevention of liver cancer in the setting of disrupted TGF-β signaling pathway
    Katz, Lior H.
    Munoz, Nina M.
    Shukla, Vivek
    Cortes, Andrea C.
    Peleg, Sara
    Shetty, Kirti
    Chen, Jian
    El-Zein, Randa
    Mishra, Lopa
    HEPATOLOGY, 2013, 58 : 1080A - 1081A
  • [26] TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
    Dropmann, Anne
    Dediulia, Tatjana
    Breitkopf-Heinlein, Katja
    Korhonen, Hanna
    Janicot, Michel
    Weber, Susanne N.
    Thomas, Maria
    Piiper, Albrecht
    Bertran, Esther
    Fabregat, Isabel
    Abshagen, Kerstin
    Hess, Jochen
    Angel, Peter
    Coulouarn, Cedric
    Dooley, Steven
    Meindl-Beinker, Nadja M.
    ONCOTARGET, 2016, 7 (15) : 19499 - 19518
  • [27] TGF-β signaling as a promising target for cancer therapy
    Kim, Seong-Jin
    CANCER SCIENCE, 2018, 109 : 558 - 558
  • [28] Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target
    Caraci, Filippo
    Spampinato, Simona Federica
    Morgese, Maria Grazia
    Tascedda, Fabio
    Salluzzo, Maria Grazia
    Giambirtone, Maria Concetta
    Caruso, Giuseppe
    Munafo, Antonio
    Torrisi, Sebastiano Alfio
    Leggio, Gian Marco
    Trabace, Luigia
    Nicoletti, Ferdinando
    Drago, Filippo
    Sortino, Maria Angela
    Copani, Agata
    PHARMACOLOGICAL RESEARCH, 2018, 130 : 374 - 384
  • [29] TGF-β Pathway as a Therapeutic Target in Bone Metastases
    Juarez, Patricia
    Guise, Theresa A.
    CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (11) : 1301 - 1312
  • [30] The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway
    Li, Jarod
    Weinberg, Marc S.
    Zerbini, Luiz
    Prince, Sharon
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (22) : 3569 - 3576
12345