Synthesis and biological activity of mycalolide analogs

被引：28
|
作者：
Suenaga, Kiyotake [1 ]
Kimura, Tomoyuki [1 ]
Kuroda, Takeshi [1 ]
Matsui, Keita [1 ]
Miya, Saori [1 ]
Kuribayashi, Satomi [1 ]
Sakakura, Akira [1 ]
Kigoshi, Hideo [1 ]
机构：
[1] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan
来源：
TETRAHEDRON | 2006年 / 62卷 / 35期
基金：
日本学术振兴会;
关键词：
D O I：
10.1016/j.tet.2006.06.046
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), a trisoxazole macrolide of marine origin, was stereoselectively synthesized using Roush crotylboration, an Evans aldol reaction, and a Paterson aldol reaction as key steps. The analog 4 was found to have strong actin-depolymerizing activity. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8278 / 8290
页数：13
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