Targeting IL-4 for the Treatment of Atopic Dermatitis

被引：0

作者：

Chiricozzi, Andrea ^{[1
,2
]}

Maurelli, Martina ^{[3
]}

Peris, Ketty ^{[1
,2
]}

Girolomoni, Giampiero ^{[3
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Med & Chirurg, Dermatol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dermatol, Rome, Italy

[3] Univ Verona, Dept Med, Sect Dermatol, Verona, Italy

来源：

IMMUNOTARGETS AND THERAPY | 2020年 / 9卷

关键词：

atopic dermatitis; IL-4; inhibitor; dupilumab; pascolizumab; pitrakinra; TH2; CYTOKINES; STAPHYLOCOCCUS-AUREUS; DERMAL FIBROBLASTS; DENDRITIC CELLS; TRANSGENIC MICE; LESIONAL SKIN; UP-REGULATION; IFN-GAMMA; IN-VITRO; T-CELLS;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is an immune-mediated inflammatory skin disease characterized by a predominant type 2 immune response. Type 2 immunity is driven by multiple cytokines, including interleukin (IL)-4 and IL-13 that are considered central to AD pathogenesis and key therapeutic targets. The dual inhibition of these two cytokines or the selective inhibition of IL-13 proved elevated efficacy in treating AD, whereas the selective inhibition of IL-4 has been poorly investigated as IL-4 inhibiting agents did not show any advance in clinical development programs. This review describes the pathogenic role of IL-4 in AD and briefly resumes the main features of compounds selectively blocking IL-4.

引用

页码：151 / 156

页数：6

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