HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas

被引:13
|
作者
Swartz, Justin E. [1 ]
Wegner, Inge [1 ,2 ]
Noorlag, Rob [3 ]
van Kempen, Pauline M. W. [1 ]
van Es, Robert J. J. [2 ,3 ]
de Bree, Remco [2 ]
Willems, Stefan M. W. [4 ]
机构
[1] Univ Med Ctr Utrecht, Dept Otorhinolaryngol Head & Neck Surg, Heidelberglaan 100, NL-3508 AB Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Head & Neck Surg Oncol, Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Dept Oral & Maxillofacial Surg, Utrecht, Netherlands
[4] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands
关键词
head and neck neoplasms; hypoxia; oropharyngeal neoplasms; survival; tumor microenvironment; TISSUE MICROARRAY TECHNOLOGY; HUMAN-PAPILLOMAVIRUS; NECK-CANCER; HYPOXIA; HEAD; RADIOTHERAPY; VALIDATION; HPV; RESISTANCE; PROGNOSIS;
D O I
10.1002/hed.26530
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite. Design/Method A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed. Results HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC. Conclusions High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.
引用
收藏
页码:745 / 756
页数:12
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