Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population

被引：41
|
作者：
Ohtsuki, T
Inada, T
Arinami, T [1 ]
机构：
[1] Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 305, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Psychiat & Psychobiol, Nagoya, Aichi, Japan
来源：
MOLECULAR PSYCHIATRY | 2004年 / 9卷 / 11期
关键词：
D O I：
10.1038/sj.mp.4001559
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
AKT1 is a serine/threonine kinase known as protein kinase B. AKT/glycogen synthase kinase 3 (GSK-3) signaling pathway might be relevant to dopamine-related disorders. Recently, AKT1 was identified as a potential schizophrenia susceptibility gene in families of northern European origin. In this study, the authors attempted to confirm the association between AKT1 haplotypes and schizophrenia in a Japanese case-control population consisting of 1126 individuals. The authors observed no significant allelic or haplotypic association.
引用
收藏
页码：981 / 983
页数：4
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