Strategies for analyzing genotype-phenotype relationships in asthma

被引：5
|
作者：
Wiesch, DG [1 ]
Meyers, DA [1 ]
机构：
[1] Univ Maryland, Sch Med, Ctr Genet Asthma & Complex Dis, Baltimore, MD 21201 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2000年 / 105卷 / 02期
关键词：
genotype; phenotype; asthma; complex disease; mendelian disease; breast cancer; cystic fibrosis; case-control study; gene-environment interaction;
D O I：
10.1016/S0091-6749(00)90047-2
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Asthma is a genetically complex disease with a multifaceted phenotype, Different approaches including population-based and family-based methods for evaluating genotype-phenotype relationships in asthma are discussed as well as the problems that may obscure these determinations. Examples of similar efforts in cystic fibrosis and breast cancer are considered in addition to interaction between causative genes and etiologically relevant environmental exposure.
引用
收藏
页码：S482 / S486
页数：5
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