Upregulation of MAPK/MCL-1 Maintaining Mitochondrial Oxidative Phosphorylation Confers Acquired Resistance to BCL-2 Inhibitor Venetoclax in AML

被引：5

作者：

Zhang, Qi ^{[1
]}

Han, Lina ^{[1
,2
]}

Shi, Ce

Pan, Rongqing ^{[1
]}

Ma, Man Chun John ^{[3
,4
]}

Ryan, Jeremy ^{[5
]}

Kurtz, Stephen E. ^{[6
]}

Mu, Hong ^{[1
]}

Ruvolo, Vivian ^{[2
]}

Ma, Helen ^{[1
]}

Andreeff, Michael ^{[1
]}

Mi, Yingchang ^{[7
]}

Tyner, Jeffrey W. ^{[8
]}

Leverson, Joel ^{[9
]}

Letai, Anthony ^{[10
]}

Davis, Richard Eric ^{[3
,4
]}

Konopleva, Marina ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA

[2] Univ Texas MD Anderson Canc Ctr, Sect Mol Hematol & Therapy, Dept Leukemia, Houston, TX USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma, Houston, TX USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Myeloma, Houston, TX USA

[5] Dana Farber Canc Inst, Harvard Med Sch, Boston, MA USA

[6] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR USA

[7] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Hosp Blood Dis, State Key Lab Expt Hematol, Tianjin, Peoples R China

[8] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR USA

[9] AbbVie Inc, N Chicago, IL USA

[10] Dana Farber Canc Inst, Boston, MA USA

来源：

BLOOD | 2016年 / 128卷 / 22期

关键词：

D O I：

10.1182/blood.V128.22.101.101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

101

引用

页数：5

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