Classical and non-classical congenital adrenal hyperplasia: What is the difference in subsequent fertility?

被引：0

作者：

Carriere, Camille ^{[1
,2
]}

Sarfati, Cynthia ^{[1
,2
,3
]}

Tejedor, Isabelle ^{[1
,2
]}

Dulon, Jerome ^{[1
,2
]}

Chakhtoura, Zeina ^{[1
,2
]}

Courtillot, Carine ^{[1
,2
]}

Bachelot, Anne ^{[1
,2
,3
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, IE3M, Dept Endocrinol & Reprod Med, Paris, France

[2] ICAN, Ctr Reference Pathol Gynecol Rares, Ctr Reference Malad Endocriniennes Rares Croissan, Paris, France

[3] Sorbonne Univ, Paris, France

来源：

ANNALES D ENDOCRINOLOGIE | 2022年 / 83卷 / 03期

关键词：

Congenital adrenal hyperplasia; 21 hydroxylase deficiency; Fertility; Pregnancy; REST TUMORS; 21-HYDROXYLASE DEFICIENCY; ADULT MALES; WOMEN; OUTCOMES; MEN; PREGNANCY; COHORT; PREVALENCE; ADOLESCENT;

D O I：

10.1016/j.o.2022.04.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

21-Hydroxylase deficiency (21OHD) is the most common cause of congenital adrenal hyperplasia. Increased production of adrenal-derived androgens and progesterone in 21OHD women interfere with their reproductive function and their fertility in many different ways, depending on the severity of the disease. Sexuality and fertility in women with classic 21OHD is impaired, due to several issues such as disrupted gonadotropic axis due to androgen and progesterone overproduction, and mechanical, psychological factors related to genital surgery. Fertility and fecundity in these women get better over the years. Subfertility seems contrariwise to be relative in non-classic 21OHD women. Before pregnancy, genotyping the partner and genetic counselling is mandatory. (c) 2022 Elsevier Masson SAS. All rights reserved.

引用

页码：181 / 185

页数：5

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