The Hedgehog pathway mediator GLI confers a negative prognosis on patients with acute myeloid leukemia and GLI inhibition results in anti-leukemic effects in vitro

被引:0
|
作者
Wellbrock, J. [1 ]
Latuske, E. [1 ]
Koehler, J. [1 ]
Wagner, K. [2 ]
Stamm, H. [1 ]
Vettorazzi, E. [3 ]
Vohwinkel, G. [1 ]
Klokow, M. [1 ]
Kuehling-Thees, R. [2 ]
Loges, S. [1 ,4 ]
Thol, F. [2 ]
Schubert, C. [5 ]
Amling, M. [6 ]
Juecker, M. [7 ]
Bokemeyer, C. [1 ]
Heuser, M. [2 ]
Krauter, J. [2 ]
Fiedler, W. [1 ]
机构
[1] Univ Klinikum Hamburg Eppendorf, Hubertus Wald Tumorzentrum, Onkol Hamatol & Knochenmarktransplantat Sekt Pneu, Med Klin & Poliklin 2, Hamburg, Germany
[2] Hannover Med Sch, Klin Hamatol Hamostaseol Onkol & Stammzelltranspl, D-30623 Hannover, Germany
[3] Univ Klinikum Hamburg Eppendorf, Inst Med Biometrie & Epidemiol, Hamburg, Germany
[4] Univ Klinikum Hamburg Eppendorf, Inst Tumorbiol, Hamburg, Germany
[5] Univ Klinikum Hamburg Eppendorf, Inst Transfus Med, Hamburg, Germany
[6] Univ Klinikum Hamburg Eppendorf, Inst Osteol & Biomech, Hamburg, Germany
[7] Univ Klinikum Hamburg Eppendorf, Inst Biochem & Signaltransdukt, Hamburg, Germany
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
V693
引用
收藏
页码:224 / 224
页数:1
相关论文
共 50 条
  • [41] Synergistic Anti-Leukemic Activity of PARP Inhibition Combined with IMGN632, an Anti-CD123 Antibody-Drug Conjugate in Acute Myeloid Leukemia Models
    Fritz, Claire
    Portwood, Scott M.
    Adams, Julie
    Cronin, Tara
    Lutgen-Dunckley, Linda
    Martens, Brandon L.
    Sloss, Callum M.
    Watkins, Krystal
    Kovtun, Yelena
    Adams, Sharlene
    Wang, Eunice S.
    BLOOD, 2018, 132
  • [42] CDK Blockade Using AT7519 Suppresses Acute Myeloid Leukemia Cell Survival through the Inhibition of Autophagy and Intensifies the Anti-leukemic Effect of Arsenic Trioxide
    Zabihi, Mitra
    Safaroghli-Azar, Ava
    Gharehbaghian, Ahmad
    Farsani, Mehdi Allahbakhshian
    Bashash, Davood
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019, 18 : 119 - 131
  • [43] Generation of lymphocytes potentiated against leukemic lymphoblasts by stimulation using leukemic cell lysate-pulsed dendritic cells in patients with acute lymphoblastic leukemia and measurement of in vitro anti-leukemic cytotoxicity
    Lim, Ji-Hun
    Park, Chan-Jeoung
    Kim, Mi-Jung
    Jang, Sungsoo
    Chi, Hyun-Sook
    Lee, Jung-Hee
    Lee, Je-Hwan
    Lee, Kyoo-Hyong
    Im, Ho-Joon
    Seo, Jong-Jin
    HEMATOLOGY, 2012, 17 (01) : 15 - 22
  • [44] A phase II study to determine the safety and anti-leukemic effects of STI571 (Glivec®) in patients with Ph positive chronic myeloid leukemia in myeloid blast crisis.
    Hochhaus, A
    Sawyers, C
    Feldman, E
    Goldman, JM
    Miller, C
    Ben-Am, M
    Capdeville, R
    Druker, B
    LEUKEMIA, 2001, 15 (03) : 488 - 488
  • [45] SGN-CD33A: Case Reports of Anti-Leukemic Activity and Bridge to Allogeneic Stem Cell Transplant (SCT) in Patients with Acute Myeloid Leukemia (AML)
    Erba, Harry P.
    Khaled, Samer K.
    Stein, Anthony S.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (02) : S185 - S186
  • [46] Anti-leukemic effects of histone edeacetylase (HDAC) inhibition in acute lymphoblastic leukemia (ALL) cells: Shedding light on mitigating effects of NF-κB and autophagy on panobinostat cytotoxicity
    Mehrpouri, Mahdieh
    Safaroghli-Azar, Ava
    Pourbagheri-Sigaroodi, Atieh
    Momeny, Majid
    Bashash, Davood
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 875
  • [47] Pan-RAF Inhibition Shows Anti-Leukemic Activity in RAS-Mutant Acute Myeloid Leukemia Cells and Potentiates the Effect of Sorafenib in Cells with FLT3 Mutation
    Khoury, Joseph D.
    Tashakori, Mehrnoosh
    Yang, Hong
    Loghavi, Sanam
    Wang, Ying
    Wang, Jing
    Piya, Sujan
    Borthakur, Gautam
    CANCERS, 2020, 12 (12) : 1 - 13
  • [48] High Expression of the Hedgehog Transcription Factor GLI1 Is Associated with Improved Outcomes in Patients with Acute Myeloid Leukemia Undergoing Hematopoietic Stem Cell Transplantation after Non-Myeloablative Conditioning
    Bill, Marius
    Jentzsch, Madlen
    Schuhmann, Luba
    Grimm, Juliane
    Knyrim, Maria
    Schmalbrock, Laura Katharina
    Karoline, Schubert
    Cross, Michael
    Vucinic, Vladan
    Franke, Georg-Nikolaus
    Poenisch, Wolfram
    Behre, Gerhard
    Lange, Thoralf
    Niederwieser, Dietger
    Schwind, Sebastian
    BLOOD, 2015, 126 (23)
  • [49] PI3K/mTOR dual-inhibition with VS-5584 enhances anti-leukemic efficacy of ponatinib in blasts and Ph-negative LSCs of chronic myeloid leukemia*
    Kayabasi, Cagla
    Yelken, Besra Ozmen
    Asik, Aycan
    Okcanoglu, Tugce Balci
    Sogutlu, Fatma
    Gasimli, Roya
    Susluer, Sunde Yilmaz
    Saydam, Guray
    Avci, Cigir Biray
    Gunduz, Cumhur
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 910
  • [50] Long-Acting E. coli-Derived Asparaginase Potentiates the Anti-Leukemic Effect of BCL2 Inhibition, but Not MCL1 Inhibition, in Preclinical Models of Acute Myeloid Leukemia
    Bollino, Dominique
    Casildo, Andrea
    Ma, Xinrong
    Tighe, Kayla M.
    Carter-Cooper, Brandon
    Emadi, Ashkan
    BLOOD, 2023, 142