The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients

被引：2

作者：

Sakai, Akiyoshi ^{[1
]}

Morishita, Tetsuji ^{[2
,3
,10
]}

Suzumuraa, Kaori ^{[1
]}

Hanatate, Fumika ^{[4
]}

Yoshikawa, Tomomi ^{[3
]}

Sasaki, Noriko ^{[3
]}

Lee, Shin ^{[5
]}

Fujita, Kei ^{[5
]}

Hara, Takeshi ^{[5
]}

Araki, Hiroshi ^{[6
]}

Tagami, Atsushi ^{[6
]}

Murayama, Masanori ^{[2
]}

Yamada, Rie ^{[2
]}

Iwata, Akira ^{[2
]}

Sobajima, Takuya ^{[2
]}

Kasahara, Yukiko ^{[7
]}

Matsuzawa, Yoriko ^{[7
]}

Takemura, Masao ^{[8
]}

Yamamoto, Yasuko ^{[8
]}

Fujigakih, Hidetsugu ^{[8
]}

Saitoh, Kuniaki ^{[8
]}

Tsurumii, Hisashi ^{[9
]}

Matsunamii, Hidetoshi ^{[9
]}

机构：

[1] Matsunami Gen Hosp, Dept Clin Lab, Gifu, Japan

[2] Matsunami Gen Hosp, Dept Internal Med, Gifu, Japan

[3] Matsunami Res Pk, Gifu, Japan

[4] Matsunami Gen Hosp, Dept Breast Surg, Gifu, Japan

[5] Matsunami Gen Hosp, Dept Hematol, Gifu, Japan

[6] Matsunami Gen Hosp, Dept Gastroenterol, Gifu, Japan

[7] Matsunami Gen Hosp, Dept Pediat, Gifu, Japan

[8] Fujita Hlth Univ, Dept Adv Diagnost Syst Dev, Grad Sch Hlth Sci, Toyoake, Aichi, Japan

[9] Matsunami Gen Hosp, Gifu, Japan

[10] Matsunami Gen Hosp, Internal Med, 185-1 Dendai, Kasamatsu, Gifu 5016062, Japan

来源：

TRANSPLANTATION PROCEEDINGS | 2022年 / 54卷 / 10期

关键词：

D O I：

10.1016/j.transproceed.2022.10.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The COVID-19 vaccine will be safe and effective in solid organ transplant recipients (SOTs). However, the blunted antibody responses were also of concern. Few studies have reported prolonged serologic follow-up after 2 doses of BNT162b2 vaccine in SOTs. We performed a sin-gle-center, prospective observational study of 78 SOTs who received 2 doses of BNT162b2 vac-cine. We identified the trajectory of antibody titers after vaccination among SOTs with or without mycophenolate mofetil (MMF) or withdrawn from MMF. We found low seroconversion rates (29/42: 69%) and low antibody titers in SOTs treated with MMF. An inverse linear relation-ship between neutralizing antibody titers and MMF concentration was confirmed in restricted cubic spline plots (P for effect < .01, P for nonlinearity = .08). For the trajectory of antibody responses, seroconversion and improved antibody titers were observed after withdrawal from MMF in SOTs who showed seronegative or low antibody titers at the first visit after 2 doses of vaccine (P for effect < .01, P for nonlinearity < .05, and P for interaction < .01). We identified increased B-cell counts after withdrawal from MMF (P < .01). The recovery of antibody responses was seen in SOTs withdrawn from MMF. The trajectories of antibody responses were modified by MMF administration.

引用

页码：2638 / 2645

页数：8

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