Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes

被引：134
|
作者：
Nadon, CA [1 ]
Bowen, BM [1 ]
Wiedmann, M [1 ]
Boor, KJ [1 ]
机构：
[1] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期
关键词：
D O I：
10.1128/IAI.70.7.3948-3952.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional sigma(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor sigma(B) contributes to virulence in L. monocytogenes.
引用
收藏
页码：3948 / 3952
页数：5
相关论文
共 50 条
  • [31] A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes
    Sleator, RD
    Wemekamp-Kamphuis, HH
    Gahan, CGM
    Abee, T
    Hill, C
    MOLECULAR MICROBIOLOGY, 2005, 55 (04) : 1183 - 1195
  • [32] Regulation of Listeria virulence: PrfA master and commander
    de las Heras, Aitor
    Cain, Robert J.
    Bielecka, Magdalena K.
    Vazquez-Boland, Jose A.
    CURRENT OPINION IN MICROBIOLOGY, 2011, 14 (02) : 118 - 127
  • [33] Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes
    Wang, Yong
    Feng, Han
    Zhu, Yalan
    Gao, Pu
    PROTEIN & CELL, 2017, 8 (04) : 308 - 312
  • [34] Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes
    Yong Wang
    Han Feng
    Yalan Zhu
    Pu Gao
    Protein & Cell, 2017, 8 (04) : 308 - 318
  • [35] Sequence variations within PrfA DNA binding sites and effects on Listeria monocytogenes virulence gene expression
    Williams, JR
    Thayyullathil, C
    Freitag, NE
    JOURNAL OF BACTERIOLOGY, 2000, 182 (03) : 837 - 841
  • [36] Glucose-1-phosphate utilization by Listeria monocytogenes is PrfA dependent and coordinately expressed with virulence factors
    Ripio, MT
    Brehm, K
    Lara, M
    Suarez, M
    VazquezBoland, JA
    JOURNAL OF BACTERIOLOGY, 1997, 179 (22) : 7174 - 7180
  • [37] How seryl-phosphorylated HPr inhibits PrfA, a transcription activator of Listeria monocytogenes virulence genes
    Herro, R
    Poncet, S
    Cossart, P
    Buchrieser, C
    Gouin, E
    Glaser, P
    Deutscher, J
    JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2005, 9 (3-4) : 224 - 234
  • [38] Negative regulation of PrfA, the key activator of Listeria monocytogenes virulence gene expression, is dispensable for bacterial pathogenesis
    Greene, SL
    Freitag, NE
    MICROBIOLOGY-SGM, 2003, 149 : 111 - 120
  • [39] Sigma B contributes to Listeria monocytogenes gastrointestinal infection but not to systemic spread in the guinea pig infection model
    Garner, MR
    Njaa, BL
    Wiedmann, M
    Boor, KJ
    INFECTION AND IMMUNITY, 2006, 74 (02) : 876 - 886
  • [40] σB- and PrfA-dependent transcription of genes previously classified as putative constituents of the Listeria monocytogenes PrfA regulon
    Ollinger, Juliane
    Wiedmann, Martin
    Boor, Kathryn J.
    FOODBORNE PATHOGENS AND DISEASE, 2008, 5 (03) : 281 - 293
12345