N-methyl-D-aspartate receptor blockade enhances neuronal apoptosis induced by serum deprivation

被引:25
|
作者
Terro, F [1 ]
Esclaire, F [1 ]
Yardin, C [1 ]
Hugon, J [1 ]
机构
[1] Fac Med Limoges, Dept Histol & Cell Biol, F-87025 Limoges, France
关键词
apoptosis; N-methyl-D-aspartate; neuron; (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine; hydrogen maleate; 2-amino-7-phosphonoheptanoic acid;
D O I
10.1016/S0304-3940(99)00911-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuronal apoptosis a hallmark of brain development could also be involved in neurodegenerative diseases. Glutamate toxicity is widely proposed as an important factor in the pathogenesis of neurological disorders. We show here that, in rat primary cortical cultures, the blockade of N-methyl-D-aspartate (NMDA) glutamate receptors exacerbated neuronal apoptosis induced by serum deprivation. This effect is observed at early stage of cultures (9 days in vitro (DIV)) and mildly decreases in more mature cultures (13 and 15 DIV). At the opposite, low concentrations of NMDA (5 mu M) or glutamate (5 mu M) prevented the neuronal apoptosis induced by trophic support withdrawal. In primary cortical cu Itu res, the proapoptotic effect of trophic support removal can be modulated by NMDA receptors depending upon the magnitude of these glutamate receptor activation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:149 / 152
页数:4
相关论文
共 50 条
  • [21] BLOCKADE OF SODIUM CURRENTS BY MODULATORS OF N-METHYL-D-ASPARTATE (NMDA) RECEPTOR CHANNEL
    CONDER, ML
    MCCULLOUGH, JR
    BIOPHYSICAL JOURNAL, 1988, 53 (02) : A539 - A539
  • [22] N-Methyl-D-Aspartate Receptor Blockade Is Neuroprotective in Experimental Autoimmune Optic Neuritis
    Suehs, Kurt-Wolfram
    Fairless, Richard
    Williams, Sarah K.
    Heine, Katrin
    Cavalie, Adolfo
    Diem, Ricarda
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2014, 73 (06): : 507 - 518
  • [23] N-methyl-D-aspartate receptor blockade attenuates D1 dopamine receptor modulation of neuronal activity in rat substantia nigra
    Huang, KX
    Bergstrom, DA
    Ruskin, DN
    Walters, JR
    SYNAPSE, 1998, 30 (01) : 18 - 29
  • [24] Prevalence of serum N-methyl-D-aspartate receptor autoantibodies in refractory psychosis
    Beck, Katherine
    Lally, John
    Shergill, Sukhwinder S.
    Bloomfield, Michael A. P.
    MacCabe, James H.
    Gaughran, Fiona
    Howes, Oliver D.
    BRITISH JOURNAL OF PSYCHIATRY, 2015, 206 (02) : 164 - 165
  • [25] The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture
    Wang, C
    Sadovova, N
    Fu, X
    Schmued, L
    Scallet, A
    Hanig, J
    Slikker, W
    NEUROSCIENCE, 2005, 132 (04) : 967 - 977
  • [26] N-METHYL-D-ASPARTATE RECEPTOR PLASTICITY IN KINDLING - QUANTITATIVE AND QUALITATIVE ALTERATIONS IN THE N-METHYL-D-ASPARTATE RECEPTOR CHANNEL COMPLEX
    YEH, GC
    BONHAUS, DW
    NADLER, JV
    MCNAMARA, JO
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) : 8157 - 8160
  • [27] The N-methyl-D-aspartate Receptor, a Precursor to N-methyl-D-aspartate Receptor Encephalitis, is Found in the Squamous Tissue of Ovarian Teratomas
    Clark, Rachel M.
    Lynch, Maureen P.
    Kolp, Rebecca
    Zukerberg, Lawrence R.
    Growdon, Whitfield B.
    Rueda, Bo R.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2014, 33 (06) : 598 - 606
  • [28] N-methyl-D-aspartate (NMDA) induced apoptosis in adult rabbit retinas
    Kwong, JMK
    Lam, TT
    EXPERIMENTAL EYE RESEARCH, 2000, 71 (04) : 437 - 444
  • [29] BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTORS PREVENTS CYANIDE-INDUCED NEURONAL INJURY IN PRIMARY HIPPOCAMPAL CULTURES
    PATEL, MN
    YIM, GKW
    ISOM, GE
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 115 (01) : 124 - 129
  • [30] Blockade of the acquisition of ethanol-induced conditioned place preference by N-methyl-D-aspartate receptor antagonists
    Biala, G
    Kotlinska, J
    ALCOHOL AND ALCOHOLISM, 1999, 34 (02): : 175 - 182