Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility

被引：12
|
作者：
Carmen Puertas, Maria [1 ]
Jose Buzon, Maria [1 ]
Artese, Anna [2 ]
Alcaro, Stefano [2 ]
Menendez-Arias, Luis [3 ,4 ]
Perno, Carlo Federico [5 ]
Clotet, Bonaventura [1 ]
Ceccherini-Silberstein, Francesca [5 ]
Martinez-Picado, Javier [1 ,6 ]
机构：
[1] IrsiCaixa Fdn, Hosp Germans Trias & Pujol, Badalona 08916, Spain
[2] Univ Catanzaro Magna Graecia, Dept Pharmacobiol Sci, Catanzaro, Italy
[3] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
[4] Univ Autonoma Madrid, Madrid, Spain
[5] Univ Roma Tor Vergata, Dept Expt Med, Rome, Italy
[6] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
来源：
JOURNAL OF VIROLOGY | 2009年 / 83卷 / 15期
关键词：
RESISTANCE MUTATIONS; ANTIRETROVIRAL THERAPY; ZIDOVUDINE RESISTANCE; VIROLOGICAL RESPONSE; EXPERIENCED PATIENTS; COMBINATION THERAPY; IN-VITRO; HIV-1; PATTERNS; INHIBITORS;
D O I：
10.1128/JVI.00487-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A negative association between polymorphism Leu-214 and type-1 thymidine analogue mutations (TAM1) and a positive association with a clinically favorable virological response to thymidine analogue-based combination antiretroviral therapy have been described. In this study, the impact of Leu-214 on replication capacity and resistance to zidovudine (ZDV) of viruses containing TAM1 or TAM2 was determined. Leu-214 decreased the growth rate of viruses bearing Tyr-215, as well as their resistance to ZDV. This observation was confirmed by structural and molecular modeling data, suggesting a regulatory role for Leu-214 in the emergence and phenotypic resistance of TAM1.
引用
收藏
页码：7434 / 7439
页数：6
相关论文
共 50 条
  • [41] NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS THAT POTENTLY AND SPECIFICALLY BLOCK HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION
    ROMERO, DL
    BUSSO, M
    TAN, CK
    REUSSER, F
    PALMER, JR
    POPPE, SM
    ARISTOFF, PA
    DOWNEY, KM
    SO, AG
    RESNICK, L
    TARPLEY, WG
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) : 8806 - 8810
  • [42] Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase
    Julias, JG
    Ferris, AL
    Boyer, PL
    Hughes, SH
    JOURNAL OF VIROLOGY, 2001, 75 (14) : 6537 - 6546
  • [43] INHIBITION OF THE REVERSE-TRANSCRIPTASE ACTIVITY AND REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 BY AS-101 INVITRO
    VONSOVER, A
    LOYA, S
    SREDNI, B
    ALBECK, M
    GOTLIEBSTEMATSKY, T
    ARAF, O
    HIZI, A
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (05) : 613 - 623
  • [44] Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1
    Corbau, Romuald
    Mori, Julie
    Phillips, Chris
    Fishburn, Lesley
    Martin, Alex
    Mowbray, Charles
    Panton, Wendy
    Smith-Burchnell, Caroline
    Thornberry, Adele
    Ringrose, Heather
    Knoechel, Thorsten
    Irving, Steve
    Westby, Mike
    Wood, Anthony
    Perros, Manos
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (10) : 4451 - 4463
  • [45] Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity
    de la Carrière, LC
    Paulous, S
    Clavel, F
    Mammano, F
    JOURNAL OF VIROLOGY, 1999, 73 (04) : 3455 - 3459
  • [46] Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and moloney murine leukemia virus reverse transcriptase
    Gao, HQ
    Sarafianos, SG
    Arnold, E
    Hughes, SH
    JOURNAL OF MOLECULAR BIOLOGY, 1999, 294 (05) : 1097 - 1113
  • [47] Sensitive phenotypic detection of minor drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants
    Nissley, DV
    Halvas, EK
    Hoppman, NL
    Garfinkel, DJ
    Mellors, JW
    Strathern, JN
    JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (11) : 5696 - 5704
  • [48] Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors
    Corona, Angela
    Schneider, Anna
    Schweimer, Kristian
    Roesch, Paul
    Woehrl, Birgitta M.
    Tramontano, Enzo
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (07) : 4086 - 4093
  • [49] Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitors
    Apsara Kandanearatchi
    Annapurna Vyakarnam
    Sabine Landau
    Ian Paul Everall
    Journal of NeuroVirology, 2004, 10 : 136 - 139
  • [50] Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitors
    Kandanearatchi, A
    Vyakarnam, A
    Landau, S
    Everall, IP
    JOURNAL OF NEUROVIROLOGY, 2004, 10 (02) : 136 - 139
12345