Synthesis of Multisubstituted Tetrahydroquinolines through Aza-Michael/Michael Addition Catalyzed by Quaternary Ammonium Salt

被引：6

作者：

Zhang, Li ^{[1
,2
]}

Li, Yajun ^{[2
,3
]}

Yuan, Yafen ^{[2
]}

Zhang, Bin ^{[2
]}

Gao, Yuan ^{[2
]}

Wu, Yongming ^{[2
]}

Song, Liping ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[3] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Hubei, Peoples R China

来源：

SYNLETT | 2014年 / 25卷 / 12期

基金：

美国国家科学基金会;

关键词：

quaternary ammonium salt; tetrahydroquinolines; Michael addition; heterocycles; INTRAMOLECULAR ALLYLIC AMINATION; HIGH-THROUGHPUT GENERATION; SOLID-PHASE SYNTHESIS; ASYMMETRIC-SYNTHESIS; QUINOLINE; MARTINELLINES; FLUORINATION; QUINAZOLINE; DESIGN;

D O I：

10.1055/s-0034-1378265

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multisubstituted tetrahydroquinolines were obtained in excellent yield from an array of N-[2-(3-oxo-3-phenylprop-1-enyl)phenyl]benzamide derivatives in a reaction catalyzed by quaternary ammonium salt. This method provides an efficient approach to the synthesis of densely substituted tetrahydroquinoline derivatives.

引用

页码：1781 / 1785

页数：5

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