Synthesis of Multisubstituted Tetrahydroquinolines through Aza-Michael/Michael Addition Catalyzed by Quaternary Ammonium Salt

被引：6
|
作者：
Zhang, Li [1 ,2 ]
Li, Yajun [2 ,3 ]
Yuan, Yafen [2 ]
Zhang, Bin [2 ]
Gao, Yuan [2 ]
Wu, Yongming [2 ]
Song, Liping [1 ]
机构：
[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[3] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Hubei, Peoples R China
来源：
SYNLETT | 2014年 / 25卷 / 12期
基金：
美国国家科学基金会;
关键词：
quaternary ammonium salt; tetrahydroquinolines; Michael addition; heterocycles; INTRAMOLECULAR ALLYLIC AMINATION; HIGH-THROUGHPUT GENERATION; SOLID-PHASE SYNTHESIS; ASYMMETRIC-SYNTHESIS; QUINOLINE; MARTINELLINES; FLUORINATION; QUINAZOLINE; DESIGN;
D O I：
10.1055/s-0034-1378265
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Multisubstituted tetrahydroquinolines were obtained in excellent yield from an array of N-[2-(3-oxo-3-phenylprop-1-enyl)phenyl]benzamide derivatives in a reaction catalyzed by quaternary ammonium salt. This method provides an efficient approach to the synthesis of densely substituted tetrahydroquinoline derivatives.
引用
收藏
页码：1781 / 1785
页数：5
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