The spindle assembly checkpoint

被引：313
|
作者：
Rudner, AD
Murray, AW
机构：
[1] Department of Physiology, Box 0444, Univ. of California at San Francisco, San Francisco, CA 94143-0444
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 06期
关键词：
D O I：
10.1016/S0955-0674(96)80077-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by inhibitory phosphorylation of Cdc2.
引用
收藏
页码：773 / 780
页数：8
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