Defects in TM6SF2 Impairs Lipidation of Nascent VLDL and Leads to Accumulation of Liver Fat

被引:0
|
作者
Martin, Sarah A.
Smagris, Eriks
Cohen, Jonathan C.
Hobbs, Helen H.
机构
来源
FASEB JOURNAL | 2018年 / 32卷 / 01期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
658.3
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer
    Newberry, Elizabeth P.
    Hall, Zoe
    Xie, Yan
    Molitor, Elizabeth A.
    Bayguinov, Peter O.
    Strout, Gregory W.
    Fitzpatrick, James A. J.
    Brunt, Elizabeth M.
    Griffin, Julian L.
    Davidson, Nicholas O.
    HEPATOLOGY, 2021, 74 (03) : 1203 - 1219
  • [32] Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial
    Scorletti, Eleonora
    West, Annette L.
    Bhatia, Lokpal
    Hoile, Samuel P.
    McCormick, Keith G.
    Burdge, Graham C.
    Lillycrop, Karen A.
    Clough, Geraldine F.
    Calder, Philip C.
    Byrne, Christopher D.
    JOURNAL OF HEPATOLOGY, 2015, 63 (06) : 1476 - 1483
  • [33] Donor TM6SF2 rs58542926 Genotype is a Risk Factor for Liver Graft Steatosis.
    Mikova, I.
    Neroldova, M.
    Hubacek, J.
    Dlouha, D.
    Kolesar, L.
    Jirsa, M.
    Honsova, E.
    Sticova, E.
    Lanska, V.
    Spicak, J.
    Trunecka, P.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 : 555 - 555
  • [34] TM6SF2: Catch-22 in the Fight Against Nonalcoholic Fatty Liver Disease and Cardiovascular Disease?
    Kahali, Bratati
    Liu, Yang-Lin
    Daly, Ann K.
    Day, Christopher P.
    Anstee, Quentin M.
    Speliotes, Elizabeth K.
    GASTROENTEROLOGY, 2015, 148 (04) : 679 - 684
  • [35] REGULATION OF TM6SF2 BY MICRORNA-432: A POTENTIAL THERAPEUTIC TARGET
    Aziziraftar, Shahrbanoo Keshavarz
    Mehraban, Mohammad
    Peaslee, Caitlin
    Somayaji, Medha
    Duwaerts, Caroline
    Le Guillou, Dounia
    Maher, Jacquelyn
    Mattis, Aras
    HEPATOLOGY, 2024, 80 : S101 - S102
  • [36] Intestinal Depletion of TM6SF2 Exacerbates High-fat Dietinduced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis
    Chen, Li-Zhen
    Wang, Yu-Rong
    Zhao, Zhen-Zhen
    Zhao, Shou-Lin
    Min, Cong-Cong
    Xin, Yong-Ning
    JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2025,
  • [37] The impact of transmembrane 6 superfamily 2 (TM6SF2) rs58542926 on liver-related events in patients with advanced chronic liver disease
    Balcar, Lorenz
    Scheiner, Bernhard
    Urheu, Markus
    Weinberger, Patrick
    Paternostro, Rafael
    Simbrunner, Benedikt
    Semmler, Georg
    Willheim, Claudia
    Pinter, Matthias
    Ferenci, Peter
    Trauner, Michael
    Reiberger, Thomas
    Staettermayer, Albert Friedrich
    Mandorfer, Mattias
    DIGESTIVE AND LIVER DISEASE, 2023, 55 (08) : 1072 - 1080
  • [38] Liver fat and whole-body insulin sensitivity are higher in newly diagnosed type 2 diabetes patients with a variant in transmembrane 6 superfamily member 2 protein (TM6SF2)
    Bodis, K.
    Szendroedi, J.
    Ahlers, J.
    Zaharia, O. -P.
    Karusheva, Y.
    Knebel, B.
    Kupriyanova, Y.
    Hwang, J. -H.
    Burkart, V.
    Al-Hasani, H.
    Muessig, K.
    Roden, M.
    Markgraf, D. F.
    DIABETOLOGIA, 2019, 62 : S171 - S171
  • [39] Effects of TM6SF2 rs58542926 polymorphism on liver triglycerides and insulin resistance in early type 2 diabetes
    Bodis, K.
    Bombrich, M.
    Schon, M.
    Knebel, B.
    Zaharia, O. -P.
    Boenhof, G.
    Kupriyanova, Y.
    Kotzka, J.
    Guthoff, R.
    Schrauwen-Hinderling, V.
    Al-Hasani, H.
    Szendroedi, J.
    Wagner, R.
    Markgraf, D.
    Roden, M.
    DIABETOLOGIA, 2023, 66 (SUPPL 1) : S202 - S203
  • [40] Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study
    Viitasalo, Anna
    Pihlajamaki, Jussi
    Paananen, Jussi
    Atalay, Mustafa
    Lindi, Virpi
    Lakka, Timo A.
    PEDIATRIC RESEARCH, 2016, 79 (05) : 684 - 688