For an integer k >= 0, suppose that each vertex v of a graph G has a set C(v) subset of {0, 1,..., k} of labels, called a list of v. A list L(2, 1)-labeling of G is an assignment of a label in C(v) to each vertex v of G such that every two adjacent vertices receive labels which differ by at least 2 and every two vertices of distance two receive labels which differ by at least 1. In this paper, we study the problem of reconfiguring one list L(2, 1)-labeling of a graph into another list L(2, 1)-labeling of the same graph by changing only one label assignment at a time, while at all times maintaining a list L(2, 1)-labeling. First we show that this decision problem is PSPACE-complete, even for bipartite planar graphs and k >= 6. In contrast, we then show that the problem can be solved in linear time for general graphs if k <= 4. We finally consider the problem restricted to trees, and give a sufficient condition for which any two list L(2, 1)-labelings of a tree can be transformed into each other. (C) 2014 Elsevier B.V. All rights reserved.