Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity

被引：3
|
作者：
Chernikova, I. B. [1 ]
Khursan, S. L. [1 ]
Eropkin, M. Yu. [2 ]
Yunusov, M. S. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Sci Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia
[2] Minist Healthcare Russian Federat, Res Inst Influenza, 15-17 Prof Popova St, St Petersburg 197376, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 02期
关键词：
5-fluorouracil; 5-chloro-5-fluoro-6-hydroxy-5; 6-dihydrouracil; antiviral activity; MYELOPEROXIDASE; 5-CHLOROURACIL;
D O I：
10.1007/s11094-019-01962-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl-2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human flu viruses A/H3N2 and A/H1N1pdm09.
引用
收藏
页码：108 / 112
页数：5
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