Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

被引：45

作者：

Sassatelli, Mathieu

Debiton, Eric

Aboab, Bettina

Prudhomme, Michelle

Moreau, Pascale

机构：

[1] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, CNRS, F-63177 Aubiere, France

[2] Univ Auvergne, Lab Pharmacognosie Biotechnol UMR 484, INSERM, Ctr Jean Perrin, F-63005 Clermont Ferrand, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 06期

关键词：

indolin-2-ones; amino acids; antiproliferative activities;

D O I：

10.1016/j.ejmech.2006.03.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Ben, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture). (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：709 / 716

页数：8

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