Iron-Catalysed Direct Aromatic Amination with N-Chloroamines

被引：7

作者：

Douglas, Gayle E. ^{[1
,2
]}

Raw, Steven A. ^{[3
]}

Marsden, Stephen P. ^{[1
,2
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England

[3] AstraZeneca, Pharmaceut Dev, Macclesfield SK10 3RN, Cheshire, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 31-32期

基金：

英国工程与自然科学研究理事会;

关键词：

Amination; Arylamines; Radicals; Homogeneous catalysis; Tetrahydroquinolines; C-H-AMINATION; VISIBLE-LIGHT; ATROPOISOMERIC P; ARENES; IMIDATION; AMIDATION; HETEROARENES; TETRAHYDROQUINOLINE; DEPROTECTION; PRECURSORS;

D O I：

10.1002/ejoc.201900614

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An optimized procedure for the direct intra- and intermolecular amination of aromatic C-H bonds with aminium radicals generated from N-chloroamines under iron catalysis is reported. A range of substituted tetrahydroquinolines could be readily prepared, while extension to the synthesis of benzomorpholines was more limited in scope. A direct one-pot variant was developed, allowing direct formal oxidative N-H/C-H coupling.

引用

页码：5508 / 5514

页数：7

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