Iron-Catalysed Direct Aromatic Amination with N-Chloroamines

被引：7
|
作者：
Douglas, Gayle E. [1 ,2 ]
Raw, Steven A. [3 ]
Marsden, Stephen P. [1 ,2 ]
机构：
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England
[3] AstraZeneca, Pharmaceut Dev, Macclesfield SK10 3RN, Cheshire, England
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 31-32期
基金：
英国工程与自然科学研究理事会;
关键词：
Amination; Arylamines; Radicals; Homogeneous catalysis; Tetrahydroquinolines; C-H-AMINATION; VISIBLE-LIGHT; ATROPOISOMERIC P; ARENES; IMIDATION; AMIDATION; HETEROARENES; TETRAHYDROQUINOLINE; DEPROTECTION; PRECURSORS;
D O I：
10.1002/ejoc.201900614
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An optimized procedure for the direct intra- and intermolecular amination of aromatic C-H bonds with aminium radicals generated from N-chloroamines under iron catalysis is reported. A range of substituted tetrahydroquinolines could be readily prepared, while extension to the synthesis of benzomorpholines was more limited in scope. A direct one-pot variant was developed, allowing direct formal oxidative N-H/C-H coupling.
引用
收藏
页码：5508 / 5514
页数：7
相关论文
共 50 条
12345