The Lesser Xing'an Range is located in the eastern segment of the Central Asian Orogenic Belt. It hosts an important polymetallic metallogenic belt that contains more than 20 large-to small-scale porphyry Mo, epithermal Au, and skarn Fe-polymetallic deposits. The Cuihongshan Fe-polymetallic deposit is one of the largest polymetallic deposits in northeastern China. To better understand the formation of the Cuihongshan Fe-polymetallic deposit, we investigated the geological characteristics of the Cuihongshan deposit and applied geochemistry and geochronology to constrain the timing of the mineralization, and characteristics of the magmas. Zircon U-Pb dating of the alkali-feldspar granite and monzogranite yielded weighted mean Pb-206/U-238 ages of 495 +/- 1.6 and 203 +/- 1 Ma, respectively. Re-Os dating on molybdenite yielded an isochron age of 203.2 +/- 1.4 Ma, and 40Ar/39Ar dating on phlogopite yielded an age of 203.4 +/- 1.3 Ma. These data suggest that mineralization occurred during the Late Triassic, and is closely related with the monzogranite emplacement. These rocks belong to the high-K calc-alkaline and subalkaline series, are enriched in Rb, U, and Th, are depleted in Nb, Ta, and Ti, and show strong Eu anomalies, implying that they are A-type post-orogenic rocks. The Cuihongshan Fe-polymetallic formation is possibly related to an extensional environment resulting from the final closure of the Paleo-Asian Ocean.