An Organocatalytic Azide-Aldehyde [3+2] Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

被引：190
|
作者：
Ramachary, Dhevalapally B. [1 ]
Shashank, Adluri B. [1 ]
Karthik, S. [1 ]
机构：
[1] Univ Hyderabad, Catalysis Lab, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 39期
关键词：
1,2,3-triazoles; aldehydes; azides; click chemistry; organocatalysis; RUTHENIUM-CATALYZED CYCLOADDITION; FREE CLICK CHEMISTRY; ALKYNE CYCLOADDITION; DIRECT ACCESS; TRIAZOLINES; EFFICIENT; INHIBITOR; KETONES; STRAIN; AMINE;
D O I：
10.1002/anie.201406721
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An organocatalytic azide-aldehyde [3+2] cycloaddition (organo-click) reaction of a variety of enolizable aldehydes is reported. The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates. It constitutes an alternative to the previously known CuAAC, RuAAC, and IrAAC click reactions.
引用
收藏
页码：10420 / 10424
页数：5
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