Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes

被引：79

作者：

Spiegler, V. ^{[1
]}

Liebau, E. ^{[2
]}

Hensel, A. ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmaceut Biol & Phytochem, Munster, Germany

[2] Univ Munster, Inst Anim Physiol, Munster, Germany

来源：

NATURAL PRODUCT REPORTS | 2017年 / 34卷 / 06期

关键词：

SAINFOIN ONOBRYCHIS-VICIIFOLIA; TRANSMITTED HELMINTH INFECTIONS; PURIFIED CONDENSED TANNINS; SOIL-INHABITING NEMATODE; VITRO LARVAL MIGRATION; 4 TROPICAL PLANTS; IN-VITRO; HAEMONCHUS-CONTORTUS; TRICHOSTRONGYLUS-COLUBRIFORMIS; CAENORHABDITIS-ELEGANS;

D O I：

10.1039/c6np00126b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyphenols comprise a structurally diverse class of natural products. As the development of new anthelmintic drugs against soil-transmitted helminthiases is an urgent need and polyphenols are widely used in the treatment of nematode infections in traditional medicine and modern science, we summarize the state of knowledge in the period of mainly 2001 up to the end of 2016 on plant extracts with known polyphenolic composition and of defined polyphenols, mainly from the classes of condensed and hydrolysable tannins, flavonoids, and phenylpropanoids. The diverse biological activity against different helminths and the underlying mechanisms are reviewed.

引用

页码：627 / 643

页数：17

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