Anticancer potential of docetaxel-loaded cobalt ferrite nanocarrier: an in vitro study on MCF-7 and MDA-MB-231 cell lines

被引：14
|
作者：
Panda, Jnanranjan [1 ]
Satapathy, Bhabani Sankar [2 ]
Mandal, Bidisha [1 ]
Sen, Ramkrishna [3 ]
Mukherjee, Biswajit [3 ]
Sarkar, Ratan [4 ]
Tudu, Bharati [1 ]
机构：
[1] Jadavpur Univ, Dept Phys, Kolkata 700032, India
[2] Siksha O Anusandhan Deemed Univ, Sch Pharmaceut Sci, Bhubaneswar, India
[3] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata, India
[4] Jogesh Chandra Chaudhuri Coll, Dept Phys, Kolkata 700033, India
来源：
JOURNAL OF MICROENCAPSULATION | 2021年 / 38卷 / 01期
关键词：
Cobalt ferrite nanoparticles; breast cancer; docetaxel; cytotoxicity; biocompatibility;
D O I：
10.1080/02652048.2020.1842529
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Aim To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d,l-lactide-co-glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells. Methods The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied. Results The CF-NP showed good crystallinity with an average particle size of 21 nm and ferromagnetic nature. The DTX-loaded CF-NP (DCF-NP) showed 8.4% (w/w) drug loading with 81.8% loading efficiency with a sustained DTX release over time. An effective internalisation and anti-proliferative efficiency was observed in MCF-7 and MDA-MB-231 breast cancer cells and negligible haemolytic effect. Conclusion The DCF-NP can have the potential for the effective delivery of DTX for breast cancer treatment.
引用
收藏
页码：36 / 46
页数：11
相关论文
共 50 条
  • [21] In vitro investigation of cytotoxic and antioxidative activities of Ardisia crispa against breast cancer cell lines, MCF-7 and MDA-MB-231
    Muhammad Luqman Nordin
    Arifah Abdul Kadir
    Zainul Amiruddin Zakaria
    Rasedee Abdullah
    Muhammad Nazrul Hakim Abdullah
    BMC Complementary and Alternative Medicine, 18
  • [22] In vitro antiproliferative effects of nab-paclitaxel with liposomal cisplatin on MDA-MB-231 and MCF-7 breast cancer cell lines
    Cetin, Idil
    Topcul, Mehmet R.
    JOURNAL OF BUON, 2017, 22 (02): : 347 - 354
  • [23] Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines
    Nik Soriani Yaacob
    Nik Nursyazni Nik Mohamed Kamal
    Mohd Nor Norazmi
    BMC Complementary and Alternative Medicine, 14
  • [24] Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines
    Yaacob, Nik Soriani
    Kamal, Nik Nursyazni Nik Mohamed
    Norazmi, Mohd Nor
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, 14
  • [25] Socs-2 expression in MCF-7 and MDA-MB-231 cells
    Farabegoli, Fulvia
    Govoni, Marzia
    CELLULAR ONCOLOGY, 2008, 30 (02) : 136 - 136
  • [26] The Kinetic Characteristics of Malic Enzyme in Human Breast Tissue Cancer Cell Lines MCF-7 and MDA-MB-231
    Ansari, Mahshid Bagherzadeh
    Shahriari, Ali
    Talaeizadeh, Abdolhossein
    Fathizadeh, Payam
    MIDDLE EAST JOURNAL OF CANCER, 2019, 10 (02) : 78 - 86
  • [27] Curcumin Conjugates Induce Apoptosis Via a Mitochondrion Dependent Pathway in MCF-7 and MDA-MB-231 Cell Lines
    Singh, Durg Vijay
    Agarwal, Shikha
    Singh, Preeti
    Godbole, Madan Madhav
    Misra, Krishna
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (10) : 5797 - 5804
  • [28] Differential Expression of HSP90β in MDA-MB-231 and MCF-7 Cell Lines after Treatment with Doxorubicin
    Jokar, Fereshte
    Mahabadi, Javad Amini
    Salimian, Morteza
    Taheriani, Aliakbar
    Hayat, Seyyed Mohammad Gheibi
    Sahebkar, Amirhossein
    Atlasi, Mohammad Ali
    JOURNAL OF PHARMACOPUNCTURE, 2019, 22 (01) : 28 - 34
  • [29] Peroxisome proliferator-activated receptor α in the human breast cancer cell lines MCF-7 and MDA-MB-231
    Suchanek, KM
    May, FJ
    Robinson, JA
    Lee, WJ
    Holman, NA
    Monteith, GR
    Roberts-Thompson, SJ
    MOLECULAR CARCINOGENESIS, 2002, 34 (04) : 165 - 171
  • [30] The Effects of Quercetin on the Apoptosis of Human Breast Cancer Cell Lines MCF-7 and MDA-MB-231: A Systematic Review
    Gol, Roghayeh Molani
    Kheirouri, Sorayya
    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2022, 74 (02): : 405 - 422
12345