Pathogenesis of necrotising enterocolitis: The impact of the altered gut microbiota and antibiotic exposure in preterm infants

被引：27

作者：

Raba, Ali Ahmed ^{[1
,2
]}

O'Sullivan, Anne ^{[2
]}

Miletin, Jan ^{[1
,2
,3
,4
]}

机构：

[1] UCD Sch Med & Med Sci, Dublin, Ireland

[2] Coombe Women & Infants Univ Hosp, Cork St, Dublin 8, Ireland

[3] Inst Care Mother & Child, Prague, Czech Republic

[4] Charles Univ Prague, Sch Med 3, Prague, Czech Republic

来源：

ACTA PAEDIATRICA | 2021年 / 110卷 / 02期

关键词：

antibiotics; microbiota; necrotising enterocolitis; preterm infants; BIRTH-WEIGHT INFANTS; INTENSIVE-CARE-UNIT; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; SEPSIS; HEALTH; RISK; ESTABLISHMENT; ASSOCIATION; COMMUNITIES;

D O I：

10.1111/apa.15559

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Necrotising enterocolitis (NEC) is a devastating condition with high morbidity and mortality seen predominately in preterm infants. Multiple factors are associated with the pathogenesis of NEC. The widespread use of antibiotics in the neonatal intensive care unit might play a role in the pathogenesis of NEC in preterm infants. This review provides a summary on the intestinal microbiota in preterm infants with a focus on how antibiotic exposure may reduce the biodiversity of the intestinal microbiota and may predispose preterm infants to NEC. Conclusion Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.

引用

页码：433 / 440

页数：8

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