Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens

被引：49

作者：

Liu, Xia ^{[1
,2
]}

Yang, Xing-Wei ^{[1
,2
]}

Chen, Chao-Qun ^{[1
]}

Wu, Chun-Yan ^{[1
]}

Zhang, Jing-Jing ^{[1
,2
]}

Ma, Jun-Zeng ^{[1
]}

Wang, Huan ^{[1
]}

Yang, Li-Xin ^{[1
]}

Xu, Gang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期

关键词：

HENRYI SUBSP URALOIDES; HYPERFORIN; BENZOPHENONES;

D O I：

10.1021/np400287r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B D (1-3) exhibited moderate inhibitory activity (IC50 5.8-17.9 mu M) against the tested tumor cell lines.

引用

页码：1612 / 1618

页数：7

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