Halogen-bond driven co-crystallization of potential anti-cancer compounds: a structural study

被引：22

作者：

Aakeroey, Christer B. ^{[1
]}

Welideniya, Dhanushi ^{[1
]}

Desper, John ^{[1
]}

Moore, Curtis ^{[2
]}

机构：

[1] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA

[2] UC San Diego Crystallog Lab, La Jolla, CA USA

来源：

CRYSTENGCOMM | 2014年 / 16卷 / 44期

关键词：

INTERMOLECULAR HYDROGEN-BOND; HEXAMETHYLENE BISACETAMIDE; DIRECTED COCRYSTALLIZATION; PHARMACEUTICAL COCRYSTALS; MOLECULAR-SOLIDS; CO-CRYSTALS; DIFFERENTIATION; FUNCTIONALITY; DESIGN; SOLUBILITY;

D O I：

10.1039/c4ce01614a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The halogen-bonding ability of a series of bis-pyridine based pharmaceutically active ingredients is explored and the structural behaviour of co-crystals thereof is compared with that of their hydrogen-bonded analogues. All co-crystals are analysed using IR spectroscopy and thirteen new crystal structures comprising iodoperfluoroalkanes and bis-pyridineacetamides are presented. Binding preferences, structural patterns and correlations between molecular and crystal structures are discussed in the context of both hydrogen-and halogen bonds.

引用

页码：10203 / 10209

页数：7

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