Eighteen-Year Follow-Up of a Retrospective Study of HLA Antibody on Kidney Graft Survival

被引：6
|
作者：
Lee, P. -C. [1 ]
Ozawa, M. [1 ]
Hung, C. -J. [1 ]
Lin, Y. -J. [1 ]
Chang, S. -S. [1 ]
Chou, T. -C. [1 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Surg, Tainan 70101, Taiwan
来源：
TRANSPLANTATION PROCEEDINGS | 2009年 / 41卷 / 01期
关键词：
RENAL-TRANSPLANTATION; RECIPIENTS;
D O I：
10.1016/j.transproceed.2008.10.078
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An increasing number of studies have demonstrated adverse graft survival in patients who have anti-HLA antibodies, whether preformed or developed posttransplantation. This retrospective study used Lambda antigen tray-mixed (LAT-M) screening and Luminex HLA class I and 11 specificity assay to re-examine the impact of pretransplantation HLA antibody on long-term graft survival. In this study, pretransplantation sera from 288 renal patients were tested using the enzyme-linked immunosorbent assay (ELISA) method, I-AT-M. Among the 234 of the patients who did not have pretransplantation antibodies, 85% enjoyed 5-year functional graft survival, 76% 10-year functional graft survival, and 56% 15-year functional graft survival. The corresponding functional graft survival for the 54 patients who tested HLA antibody-positive was 65%, 53%, and 28%, respectively (P =.0021).
引用
收藏
页码：121 / 123
页数：3
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