SILICA GEL CATALYZED SYNTHESIS OF QUINOXALINE 1,4-DIOXIDES UNDER SOLVENT-FREE CONDITIONS USING MICROWAVE IRRADIATION

被引：5
|
作者：
Sumiyoshi, Yusuke [1 ]
Saito, Hiroaki [1 ]
Miyairi, Shinichi [1 ]
Takabatake, Tohru [1 ]
机构：
[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan
来源：
HETEROCYCLES | 2009年 / 78卷 / 04期
关键词：
Benzofuroxan; Benzofurazan; Dehydration; BENZOFUROXAN; ALUMINA;
D O I：
10.3987/COM-08-11588
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report on the simple and quick synthesis of quinoxaline 1,4-dioxides in solvent-free conditions under microwave irradiation. Heating of various benzofuroxans and beta-ketoesters or 1,3-diketones adsorbed on silica gel in a microwave oven for two minutes affords diverse biologically attractive quinoxaline 1,4-dioxides in high to excellent yields. Silica gel functions not only as support using microwave but also as catalyst and dehydration reagent.
引用
收藏
页码：905 / 909
页数：5
相关论文
共 50 条
  • [21] Synthesis of 1,4-dihydropyridines under solvent-free conditions
    Zolfigol, MA
    Safaiee, M
    SYNLETT, 2004, (05) : 827 - 828
  • [22] Synthesis of Quinoxaline Derivatives Catalyzed by Bronsted Acidic Ionic Liquid under Solvent-Free Conditions
    Chatterjee, Rana
    Mahato, Sachinta
    Mukherjee, Anindita
    Zyryanov, Grigory, V
    Majee, Adinath
    MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2019), 2020, 2280
  • [23] Fluoroboric acid adsorbed on silica gel catalyzed synthesis of bisindolyl alkanes under mild and solvent-free conditions
    Bandgar, B. P.
    Patil, Abasaheb. V.
    Kamble, V. T.
    ARKIVOC, 2007, : 252 - 259
  • [24] ONE-STEP SYNTHESIS OF QUINOXALINE 1,4-DIOXIDES AND RELATED COMPOUNDS
    ABUSHANA.E
    JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (12): : 4279 - &
  • [25] Preparation of phenytoin derivatives under solvent-free conditions using microwave irradiation
    Safari, J.
    Naeimi, H.
    Ghanbari, M. M.
    Fini, O. Sabzi
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 45 (03) : 477 - 479
  • [26] Preparation of phenytoin derivatives under solvent-free conditions using microwave irradiation
    J. Safari
    H. Naeimi
    M. M. Ghanbari
    O. Sabzi Fini
    Russian Journal of Organic Chemistry, 2009, 45 : 477 - 479
  • [27] Heck reactions under microwave irradiation in solvent-free conditions
    DiazOrtiz, A
    Prieto, P
    Vazquez, E
    SYNLETT, 1997, (03) : 269 - &
  • [28] Silica gel supported sodium hydrogen sulfate as an efficient and reusable heterogeneous catalyst for the synthesis of imines in solvent-free conditions under microwave irradiation
    Gopalakrishnan, M
    Sureshkumar, P
    Kanagarajan, V
    Thanusu, J
    Govindaraju, R
    JOURNAL OF CHEMICAL RESEARCH, 2005, (05) : 299 - 303
  • [29] A NEW SYNTHESIS OF 2,3-DISUBSTITUTED QUINOXALINE 1,4-DIOXIDES CATALYZED BY MOLECULAR-SIEVES
    TAKABATAKE, T
    HASEGAWA, M
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, 24 (02) : 529 - 530
  • [30] Catalytic activity of silica gel in the synthesis of sulfonamides under mild and solvent-free conditions
    Jafarpour, Maasoumeh
    Rezaeifard, Abdolreza
    Aliabadi, Marzieh
    APPLIED CATALYSIS A-GENERAL, 2009, 358 (01) : 49 - 53
12345