Development of Nano-hydroxyapatite/Polycarbonate Composite for Bone Repair

被引：14

作者：

Liao Jianguo ^{[3
]}

Zhang Li ^{[1
,2
]}

Zuo Yi ^{[1
,2
]}

Wang Huanan ^{[1
,2
]}

Li Jidong ^{[1
,2
]}

Zou Qin ^{[1
,2
]}

Li Yubao ^{[1
,2
]}

机构：

[1] Sichuan Univ, Res Ctr Nanobiomat, Chengdu 610064, Peoples R China

[2] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610064, Peoples R China

[3] Henan Polytechn Univ, Sch Mat Sci & Engn, Jiaozuo 454000, Peoples R China

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2009年 / 24卷 / 01期

关键词：

nano-hydroxyapatite; polycarbonate; bone substitute; biocompatibility; composite; SURFACE MODIFICATION; APATITE; GROWTH;

D O I：

10.1177/0885328209102756

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this study, nano-hydroxyapatite (n-HA) combined polycarbonate was synthesized by a novel method. The physical and chemical property of the composite was tested. The results indicated the n-HA a crystal has the similar grain size, phase composition and crystal structure as. TEM photos results show the n-HA crystals were uniformly distributed in the polymer matrix. Then, the chemical bond between inorganic n-HA and polycarbonate was investigated and discussed. Proliferation of MSCs/composite cultured for up to 11 days the adhesion were tested by MTT and SEM. The in vitro test confirmed that the n-HA/PC composite was biocompatible and no negative effect on MSCs has found. The composite is proved to be osteoconductive, and can stimulate the growth of new bone. These results indicated that the composite meet the basic requirement of bone substitute material, and be potentially applied for clinic.

引用

页码：31 / 45

页数：15

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