Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats

被引：22
|
作者：
Abdullah, Mohammad M. [2 ,3 ]
Riediger, Natalie N. [2 ,3 ]
Chen, Qilin [4 ]
Zhao, Zhaohui [2 ,3 ]
Azordegan, Nazila [2 ,3 ]
Xu, Zuyuan [2 ,3 ]
Fischer, Gabor [5 ]
Othman, Rgia A. [2 ,3 ]
Pierce, Grant N. [6 ]
Tappia, Paramjit S. [2 ,7 ]
Zou, Jitao [4 ]
Moghadasian, Mohammed H. [1 ,2 ,3 ]
机构：
[1] St Boniface Gen Hosp, Res Ctr, Pathol Res Lab, Winnipeg, MB R2H 2A6, Canada
[2] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB, Canada
[3] Univ Manitoba, Canadian Ctr Agri Food Res Hlth & Med, Winnipeg, MB, Canada
[4] Natl Res Council Canada, Inst Plant Biotechnol, Saskatoon, SK S7N 0W9, Canada
[5] St Boniface Gen Hosp, Dept Pathol, Winnipeg, MB R2H 2A6, Canada
[6] St Boniface Hosp Res Ctr, Dept Physiol, Winnipeg, MB, Canada
[7] St Boniface Gen Hosp, IH Asper Clin Res Inst, Winnipeg, MB R2H 2A6, Canada
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2009年 / 327卷 / 1-2期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Cardiovascular disease; Diabetes; Fatty acid; Fructose; Liver; Rats; COUNTERREGULATORY RESPONSES; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC LOAD; OBESITY; MECHANISMS; GLUCOSE; CARBOHYDRATE; HYPOGLYCEMIA; PHYTOSTEROLS;
D O I：
10.1007/s11010-009-0063-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.
引用
收藏
页码：247 / 256
页数：10
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