Synthetic approaches to rapamycin .3. Synthesis of a C1-C21 fragment

被引：0
|
作者：
Harris, L
Jarowicki, K
Kocienski, P
机构：
[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND
[2] GLAXO WELLCOME RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND
来源：
SYNLETT | 1996年 / 09期
关键词：
rapamycin; asymmetric allylation; asymmetric hydrogenation; Heck reaction; immunosuppressant; ketenedithioacetal; alpha-oxoketene;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Key steps in two alternative approaches to the C10-C21 fragments 4 and 17 of the immunosuppressant rapamycin employ catalytic asymmetric allylation and catalytic asymmetric hydrogenation to introduce the first stereogenic centre at C14. Appendage of C1-C9 via trapping of an a-oxoketene intermediate generates the C1-C21 fragment 5.
引用
收藏
页码：903 / &
页数：4
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