The neuroprotective effect of heme oxygenase (HO) on oxidative stress in HO-1 siRNA-transfected HT22 cells

被引：30
|
作者：
Kaizaki, Asuka
Tanaka, Sachiko
Ishige, Kumiko
Numazawa, Satoshi
Yoshida, Takemi
机构：
[1] Showa Univ, Sch Pharmaceut Sci, Dept Biochem Toxicol, Tokyo 1428555, Japan
[2] Nihon Univ, Coll Pharm, Dept Pharmacol, Chiba 2748555, Japan
来源：
BRAIN RESEARCH | 2006年 / 1108卷
关键词：
HT22; cell; siRNA; heme oxygenase; bilirubin; oxidative stress; neuronal cell death;
D O I：
10.1016/j.brainres.2006.06.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To investigate the role of heme oxygenase (HO) isozymes, we used siRNA technology to suppress HO-1 expression. HO-1 siRNA-transfected HT22 cells were vulnerable to hydrogen peroxide- and 4-hydroxynonenal-induced cytotoxicity. Biliverdin and bilirubin, degradative products of heme catalyzed by HO, protected HT22 cells from the insult of these oxidative stressors. These results suggest that inducible HO-1 plays a protective role against oxidative stress in HT22 cells. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：39 / 44
页数：6
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