Prenylated Indole Alkaloid Derivatives from Marine Sediment-Derived Fungus Penicillium paneum SD-44

被引：17
|
作者：
Li, Chun-Shun [1 ]
Li, Xiao-Ming [1 ]
An, Chun-Yan [1 ]
Wang, Bin-Gui [1 ]
机构：
[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
来源：
HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Penicillium paneum; -Carbolines; Alkaloids; Indole alkaloids; NATURAL-PRODUCTS;
D O I：
10.1002/hlca.201400035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three new prenylated indole alkaloids, including two -carbolines, penipalines A and B (1 and 2, resp.), and one indole carbaldehyde derivative, penipaline C (3), as well as two known indole derived analogs, 4 and 5, were isolated from the deep-sea-sediment derived fungus Penicillium paneum SD-44 cultured in a 500-l bioreactor. The structures of the new compounds were determined on the basis of 1D- and 2D-NMR spectroscopy, as well as by high-resolution mass spectrometry. The new compounds 2 and 3 showed potent cytotoxic activities against A-549 and HCT-116 cell lines.
引用
收藏
页码：1440 / 1444
页数：5
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